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S-Gliptin Plus (Sitagliptin+Metformin) 50mg+1000mg Tablets, 14 Ct - Barrett Hodgson Spironolactone is a pharmaceutical product withMetformin 1000mg primarily works by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues. It inhibits the mitochondrial respiratory chain complex I, leading to reduced ATP production and decreased hepatic glucose output. Additionally, metformin improves insulin mediated glucose uptake in skeletal muscle and adipose tissue. On the other hand, Sitagliptin 50mg, a dipeptidyl peptidase 4 (DPP 4) inhibitor, acts